2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Squalene Monooxygenase

Squalene Monooxygenase 

Squalene Monooxygenase, SQLE, Squalene Epoxidase

Squalene epoxidase (SQLE), also named squalene monooxygenase, is a FAD-containing enzyme in the endoplasmatic reticulum. SQLE catalyzes the epoxidation of squalene to produce 2,3-oxidosqualene in the presence of NADPH, a key step in cholesterol biosynthesis. SQLE is a direct target of SREBP2 transcription factor that regulates the majority of genes in the cholesterol biosynthetic pathway[1][2].

Squalene Monooxygenase 相关产品 (1):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-W020246
    Tetramethylthiuram monosulfide Inhibitor 99.71%
    Tetramethylthiuram monosulfide 是一种口服有效的微粒体单加氧酶 (monooxygenases) 抑制剂。Tetramethylthiuram monosulfide 减少棕榈酸掺入微粒体磷脂，破坏微粒体膜完整性，并损害氧合过程中的电子传递。Tetramethylthiuram monosulfide 可诱发点突变，对 CCl4 诱导的肝损伤具有改善作用，具备杀真菌和杀菌活性，同时是一种弱接触致敏剂。Tetramethylthiuram monosulfide 可用于变应性接触性皮炎的相关研究。
    Tetramethylthiuram monosulfide
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